abstract：:Enterotoxigenic E. coli (ETEC) and Shigella are enteropathogens causing significant global morbidity and mortality, particularly in low-income countries. No licensed vaccine exists for either pathogen, but candidates are in development, with the most advanced candidates potentially approaching pivotal efficacy testing...

journal_title：Vaccine

authors： Hosangadi D,Smith PG,Giersing BK

更新日期：2019-11-28 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a leading viral cause of respiratory morbidity and mortality in infants and young children worldwide. Low and middle income countries (LMICs) account for approximately 99% of the global mortality estimates in this population, with up to 200,000 RSV deaths per year. The vaccine prod...

journal_title：Vaccine

authors： Giersing BK,Karron RA,Vekemans J,Kaslow DC,Moorthy VS

更新日期：2019-11-28 00:00:00

abstract：:HPV vaccines are highly immunogenic. A two-dose schedule for 9-14 year-old is recommended. However, no data exist regarding the impact of age, menarche status and body mass index (BMI) on the immune response to a two-dose schedule. In this post-hoc analysis, we present antibody titers to HPV6/11/16/18 in 9-13 year-old...

journal_title：Vaccine

authors： Sauvageau C,Gilca V,Donken R,Fan SY,Ogilvie G,Dobson S

更新日期：2019-11-20 00:00:00

abstract：:Although West Nile virus (WNV) causes annual cases of neurological disease and deaths in humans, a vaccine has not been licensed for human use. Several WNV genes have been targeted for mutagenesis in attempts to generate live attenuated vaccine candidates, including the non-structural protein NS5. Specifically, mutati...

journal_title：Vaccine

authors： Kaiser JA,Luo H,Widen SG,Wood TG,Huang CY,Wang T,Barrett ADT

更新日期：2019-11-15 00:00:00

abstract：:The Ebola virus epidemic in West Africa proved to be the largest in the history of filovirus outbreaks, causing the World Health Organization to declare a public health emergency of international concern in August of 2014. In collaboration with domestic and international partners, the Biomedical Advanced Research and ...

journal_title：Vaccine

authors： Wolfe DN,Zarrabian AG,Disbrow GL,Espeland EM

更新日期：2019-11-15 00:00:00

abstract：INTRODUCTION:Clinical trial data management (DM) conducted during outbreaks like that of Ebola virus disease (EVD) in West Africa, 2014-2016, has to adapt to specific, unique circumstances. CTU Bern was asked to set up a safe data capture/management system that could be launched within a few weeks and cover two differe...

journal_title：Vaccine

authors： Hossmann S,Haynes AG,Spoerri A,Diatta ID,Aboubacar B,Egger M,Rintelen F,Trelle S

更新日期：2019-11-15 00:00:00

abstract：:Ebola virus (EBOV) is among the deadliest pathogens known to man causing infrequent outbreaks of hemorrhagic disease. In humans, the case fatality rates in the outbreaks can reach 90%. During the West African epidemic almost 30,000 people were infected and of these over 11,000 fatalities were reported. Currently, we a...

journal_title：Vaccine

authors： Lehrer AT,Wong TS,Lieberman MM,Johns L,Medina L,Feldmann F,Feldmann H,Marzi A

更新日期：2019-11-08 00:00:00

abstract：:Vaccine induced responses are often weaker in those individuals most susceptible to infection, namely the very young and the elderly, highlighting the need for safe and effective vaccine adjuvants. Herein we evaluated different archaeosome formulations as an adjuvant to the H1N1 influenza hemagglutinin protein and com...

journal_title：Vaccine

authors： Stark FC,Akache B,Ponce A,Dudani R,Deschatelets L,Jia Y,Sauvageau J,Williams D,Jamshidi MP,Agbayani G,Wachholz K,Harrison BA,Li X,Krishnan L,Chen W,McCluskie MJ

更新日期：2019-11-08 00:00:00

abstract：:A flow cytometry-based assay was developed to assess the infective titer of two recombinant viruses: a recombinant herpes simplex type 2 (rHSV-2) and a recombinant canary pox (rALVAC.gfp). This method uses granularity of infected Vero and QT-35 cells, respectively, and correlates this to the infectious titer of virus ...

journal_title：Vaccine

authors： Logan M,Manalil J,Notte C,Kearse C,George S,Zeiser A,Farrell P,Aucoin MG

更新日期：2019-11-08 00:00:00

abstract：AIM:Design and immunogenicity assessment of the combined vaccine candidate against zoonotic hepatitis E virus (HEV) and foot-and-mouth disease virus (FMDV). METHODS:Using the molecular cloning technology, we produced and purified 9 HEV ORF2-truncated proteins (HEV genotype 4). Then, we compared their thermal stability...

journal_title：Vaccine

authors： Liu Z,Behloul N,Baha S,Wei W,Shi R,Meng J

更新日期：2019-10-31 00:00:00

abstract：BACKGROUND:While childhood vaccines are safe and effective, some parents remain hesitant to vaccinate their children, which has led to outbreaks of vaccine preventable diseases. The goal of this systematic review was to identify and summarize the range of beliefs around childhood vaccines elicited using open-ended ques...

journal_title：Vaccine

authors： Gidengil C,Chen C,Parker AM,Nowak S,Matthews L

更新日期：2019-10-23 00:00:00

abstract：:Concerns about bioterrorism and outbreaks of zoonotic orthopoxvirus require safe and efficacious smallpox vaccines. We previously reported the clinical efficacy and safety profiles of LC16m8, a live, attenuated, cell culture-derived, smallpox vaccine, examined in over 3000 healthy Japanese adults with various vaccinat...

journal_title：Vaccine

authors： Eto A,Fujita M,Nishiyama Y,Saito T,Molina DM,Morikawa S,Saijo M,Shinmura Y,Kanatani Y

更新日期：2019-10-16 00:00:00

abstract：:Pre-fusion stabilizing mutations (DS-Cav1) in soluble fusion (F) proteins of human respiratory syncytial virus (RSV) were previously reported. Here we investigated the antigenic and immunogenic properties of pre-fusion like RSV F proteins on enveloped virus-like particles (VLP). Additional mutations were introduced to...

journal_title：Vaccine

authors： Kwon YM,Lee Y,Kim KH,Jung YJ,Li Z,Jeeva S,Lee S,Moore ML,Kang SM

更新日期：2019-10-16 00:00:00

abstract：BACKGROUND:In 2017, measles elimination was verified in Bhutan, and the country appears to have sufficiently high vaccination coverage to achieve rubella elimination. However, a measles and rubella serosurvey was conducted to find if any hidden immunity gaps existed that could threaten Bhutan's elimination status. MET...

journal_title：Vaccine

authors： Wangchuk S,Nogareda F,Tshering N,Khandu L,Pelden S,Wannemuehler K,Wangdi S,Wangchuk U,Mulders M,Tamang T,Patel MK

更新日期：2019-10-08 00:00:00

abstract：:Neospora caninum is a causative and transmissible agent of dog and bovine neosporosis. The resulting reproductive failures in infected cattle lead to significant economic losses worldwide. However, there is no satisfactory treatment or vaccine currently available to combat this pathogen. Thus, the development of appro...

journal_title：Vaccine

authors： Xu J,Hiramatsu R,Suhaimi H,Kato T,Fujimoto A,Tokiwa T,Ike K,Park EY

更新日期：2019-10-08 00:00:00

abstract：:Lactobacillus spp. comprise a large group of Gram-positive lactic acid bacteria with varying physiological, ecological and immunomodulatory properties that are widely exploited by mankind, primarily in food production and as health-promoting probiotics. Recent years have shown increased interest in using lactobacilli ...

journal_title：Vaccine

authors： Kuczkowska K,Øverland L,Rocha SDC,Eijsink VGH,Mathiesen G

更新日期：2019-10-08 00:00:00

abstract：BACKGROUND:Rabies is a neglected zoonotic disease with a global burden of approximately 59,000 human deaths a year. Once clinical symptoms appear, rabies is almost invariably fatal; however, with timely and appropriate post-exposure prophylaxis (PEP) consisting of wound washing, vaccine, and in some cases rabies immuno...

journal_title：Vaccine

authors： Sreenivasan N,Li A,Shiferaw M,Tran CH,Wallace R,Blanton J,Knopf L,Abela-Ridder B,Hyde T,Working group on Rabies PEP logistics.

更新日期：2019-10-03 00:00:00

abstract：:Seasonal influenza vaccines represent a positive intervention to limit the spread of the virus and protect public health. Yet continual influenza evolution and its ability to evade immunity pose a constant threat. For these reasons, vaccines with improved potency and breadth of protection remain an important need. We ...

journal_title：Vaccine

authors： Rudicell RS,Garinot M,Kanekiyo M,Kamp HD,Swanson K,Chou TH,Dai S,Bedel O,Simard D,Gillespie RA,Yang K,Reardon M,Avila LZ,Besev M,Dhal PK,Dharanipragada R,Zheng L,Duan X,Dinapoli J,Vogel TU,Kleanthous H,Mascola J

更新日期：2019-09-30 00:00:00

abstract：:Wildebeest-associated malignant catarrhal fever (WA-MCF), a fatal disease of cattle caused by alcelaphine herpesvirus 1 (AlHV-1), is one of the most important seasonal diseases of cattle in wildebeest endemic areas, with annual incidence reaching 10%. Here we report efficacy of over 80% for a vaccine based on the atte...

journal_title：Vaccine

authors： Cook E,Russell G,Grant D,Mutisya C,Omoto L,Dobson E,Lankester F,Nene V

更新日期：2019-09-20 00:00:00

abstract：:Vaccines prevent an estimated 2.5 million deaths worldwide each year and are amongst the most cost-effective preventive measures against infectious diseases. Despite the effectiveness and availability of vaccines in many parts of the world, vaccination rates and service uptake remains suboptimal among both healthcare ...

journal_title：Vaccine

authors： Poudel A,Lau ETL,Deldot M,Campbell C,Waite NM,Nissen LM

更新日期：2019-09-20 00:00:00

abstract：:Eight different vaccination schemes using four commercially available inactivated Bluetongue vaccines against serotypes 4 and 8 in three different combinations (setting 1-3) were tested under field conditions for their ability to generate a measurable immune response in sheep. Animals of setting 1 (groups A-D) were si...

journal_title：Vaccine

authors： Hilke J,Strobel H,Woelke S,Stoeter M,Voigt K,Grimm L,Meilwes J,Punsmann T,Blaha I,Salditt A,Rohn K,Bastian M,Ganter M

更新日期：2019-09-16 00:00:00

abstract：BACKGROUND:The world's first dengue vaccine [Dengvaxia; Sanofi Pasteur] was licensed in 2015 and others are in development. Real-world evaluations of dengue vaccines will therefore soon be needed. We assessed feasibility of case control (CC) and test-negative (TN) design studies for dengue vaccine effectiveness by meas...

journal_title：Vaccine

authors： Nealon J,Lim WY,Moureau A,Linus Lojikip S,Junus S,Kumar S,Nachiappan JP,Devi Sekaran S,Radigue C,Cowling BJ,Ochiai RL,Hss AS

更新日期：2019-09-16 00:00:00

abstract：BACKGROUND:Two MenB vaccines with different dosing schedules are approved in the US: MenB-4C (2 doses) and MenB-FHbp (2-3 doses). Both vaccines were licensed on the basis of immunogenicity demonstrated after vaccine series completion. We evaluated vaccination completion and adherence to dosing schedules. METHODS:This ...

journal_title：Vaccine

authors： Packnett E,Irwin DE,Novy P,Watson PS,Whelan J,Moore-Schiltz L,Lucci M,Hogea C

更新日期：2019-09-16 00:00:00

abstract：OBJECTIVE:Evidence-based strategies to address vaccine hesitancy are lacking. Personal values are a measurable psychological construct that could be used to deliver personalized messages to influence vaccine hesitancy and behavior. Our objectives were to develop a valid, reliable self-report survey instrument to measur...

journal_title：Vaccine

authors： Cataldi JR,Sevick C,Pyrzanowski J,Wagner N,Brewer SE,Narwaney KJ,Shoup JA,Resnicow K,Glanz J,Dempsey A,Kwan BM

更新日期：2019-09-10 00:00:00

abstract：:Extending the benefits of vaccination to everyone who is eligible requires an understanding of which populations current vaccination efforts have struggled to reach. A clear definition of "hard-to-reach" populations - also known as high-risk or marginalized populations, or reaching the last mile - is essential for est...

journal_title：Vaccine

authors： Ozawa S,Yemeke TT,Evans DR,Pallas SE,Wallace AS,Lee BY

更新日期：2019-09-03 00:00:00

abstract：:Lyme disease (LD) accounts for over 70% of tick-borne disease reported in the United States. The disease in humans is characterized by skin rash, arthritis, cardiac and neurological signs. Vaccination is the most efficient preventive measure that could be taken to reduce the incidence of the LD worldwide; however, at ...

journal_title：Vaccine

authors： Hassan WS,Giaretta PR,Rech R,Ollivault-Shiflett M,Esteve-Gasent MD

更新日期：2019-09-03 00:00:00

abstract：:Lassa fever remains the most imported viral haemorrhagic fever in Europe and is responsible for 5000 deaths per year throughout Western Africa. There is no vaccine and treatment is often ineffective. We have developed a vaccine based on modified Vaccinia Ankara expressing the nucleoprotein from Lassa virus (MVALassaNP...

journal_title：Vaccine

authors： Kennedy EM,Dowall SD,Salguero FJ,Yeates P,Aram M,Hewson R

更新日期：2019-08-23 00:00:00

abstract：BACKGROUND:A vaccine manufacturer in China and regulatory authorities have been the focus of widespread outrage due to a vaccine scandal. We conducted a rapid survey during a time of intense mainstream and social media attention to determine whether the public's confidence in vaccines was affected. METHODS:We selected...

journal_title：Vaccine

authors： Han B,Wang S,Wan Y,Liu J,Zhao T,Cui J,Zhuang H,Cui F

更新日期：2019-08-23 00:00:00

abstract：BACKGROUND:Postherpetic neuralgia (PHN) occurs in 5-30% of individuals with herpes zoster (HZ) and is characterized by long-lasting pain. Zoster vaccine live (ZVL) is licensed for people 50 years and older to prevent HZ and PHN. This study evaluated vaccine effectiveness (VE) of ZVL against PHN. METHODS:We conducted a...

journal_title：Vaccine

authors： Klein NP,Bartlett J,Fireman B,Marks MA,Hansen J,Lewis E,Aukes L,Saddier P

更新日期：2019-08-23 00:00:00

abstract：OBJECTIVE:In response to the emergence of influenza viruses with pandemic potential, we evaluated a swine-origin influenza A/H3N2 variant (H3N2v) vaccine in children. STUDY DESIGN:This multicenter phase II open-label study assessed the safety and immunogenicity of two doses, 21 days apart, of investigational unadjuvan...

journal_title：Vaccine

authors： Munoz FM,Anderson EJ,Bernstein DI,Harrison CJ,Pahud B,Anderson E,Creech CB,Berry AA,Kotloff KL,Walter EB,Atmar RL,Bellamy AR,Chang S,Keitel WA

更新日期：2019-08-23 00:00:00

abstract：BACKGROUND:Childhood vaccinations reduce morbidity and mortality and are highly cost-effective. They may also protect children from malnutrition and lead to improved child growth. Stunting, wasting and underweight are targets used to monitor progress towards the achievement of the sustainable development goals (SDGs). ...

journal_title：Vaccine

authors： Bogler L,Jantos N,Bärnighausen T,Vollmer S

更新日期：2019-08-14 00:00:00

abstract：:In response to global interest in the development of a universal influenza vaccine, the Bill & Melinda Gates Foundation, PATH, and the Global Funders Consortium for Universal Influenza Vaccine Development convened a meeting of experts (London, UK, May 2018) to assess the role of a standardized controlled human influen...

journal_title：Vaccine

authors： Innis BL,Scorza FB,Blum JS,Jain VK,Aguilar AO,Post DJ,Roberts PC,Wairagkar N,White J,Bresee J

更新日期：2019-08-14 00:00:00

abstract：:Rabies virus remains an important burden of disease claiming an estimated 60,000 lives each year, mainly children, and having a huge economical and societal cost. Post-exposure prophylaxis (PEP) is highly effective, however in patients that present with neurological symptoms the case-fatality ratio is extremely high (...

journal_title：Vaccine

authors： Jochmans D,Neyts J

更新日期：2019-08-02 00:00:00

abstract：OBJECTIVE:To compare the economic impact of high-dose trivalent (HD) versus standard-dose trivalent (SD) influenza vaccination on direct medical costs for cardio-respiratory hospitalizations in adults aged 65 years or older enrolled in the United States (US) Veteran's Health Administration (VHA). METHODS:Leveraging a ...

journal_title：Vaccine

authors： van Aalst R,Russo EM,Neupane N,Mahmud SM,Mor V,Wilschut J,Chit A,Postma M,Young-Xu Y

更新日期：2019-07-26 00:00:00

abstract：INTRODUCTION:The strategy to Eliminate Yellow Fever Epidemics (EYE) is a global initiative that includes all countries with risk of yellow fever (YF) virus transmission. Of these, 40 countries (27 in Africa and 13 in the Americas) are considered high-risk and targeted for interventions to increase coverage of YF vaccin...

journal_title：Vaccine

authors： Adrien N,Hyde TB,Gacic-Dobo M,Hombach J,Krishnaswamy A,Lambach P

更新日期：2019-07-26 00:00:00

abstract：:Chitosan is a polysaccharide capable of augmenting immune responses with a proven safety record in animals and humans. These properties make it a potentially attractive agent for the prevention and treatment of infectious disease. Infection by respiratory syncytial virus (RSV) is the leading cause of serious lower res...

journal_title：Vaccine

authors： Muralidharan A,Russell MS,Larocque L,Gravel C,Sauvé S,Chen Z,Li C,Chen W,Cyr T,Rosu-Myles M,Wang L,Li X

更新日期：2019-07-09 00:00:00

abstract：:Widespread use of Pneumococcal Conjugate Vaccines (PCV) has reduced vaccine-type nasopharyngeal colonisation and invasive pneumococcal disease. In a double-blind, randomised controlled trial using the Experimental Human Pneumococcal Challenge (EHPC) model, PCV-13 (Prevenar-13) conferred 78% protection against colonisa...

journal_title：Vaccine

authors： German EL,Solórzano C,Sunny S,Dunne F,Gritzfeld JF,Mitsi E,Nikolaou E,Hyder-Wright AD,Collins AM,Gordon SB,Ferreira DM

更新日期：2019-07-09 00:00:00

abstract：:In this work, we explore the effects of O-acetylation on the physical and immunological characteristics of the WHO International Standards of Vi polysaccharide (Vi) from both Citrobacter freundii and Salmonella enterica serovar Typhi. We find that, although structurally identical according to NMR, the two Vi standards...

journal_title：Vaccine

authors： Hitri K,Kuttel MM,De Benedetto G,Lockyer K,Gao F,Hansal P,Rudd TR,Beamish E,Rijpkema S,Ravenscroft N,Bolgiano B

更新日期：2019-06-27 00:00:00

abstract：BACKGROUND:The demand on effective and safe anthrax vaccine is increasing as a part of the preparedness for possible bioterrorism in the future. We performed a randomized, single-blind, placebo controlled phase II clinical study to evaluate the immunogenicity and safety of a novel recombinant protective antigen (rPA) a...

journal_title：Vaccine

authors： Kang CK,Kim NH,Kim CJ,Rhie GE,Jo SK,Ahn M,Kang J,Choe PG,Park WB,Kim NJ,Oh MD

更新日期：2019-06-27 00:00:00

abstract：BACKGROUND:Measles-containing vaccine (MCV) was introduced in 1965 in Beijing and given to the children aged 8m-14y. In population-based surveillance system, real-time polymerase chain reaction (RT-PCR) and immunoglobulin M(IgM) serology tests have been conducted for each suspected case since 2013. We used the surveill...

journal_title：Vaccine

authors： Ma R,Lu L,Suo L,Zhangzhu J,Chen M,Pang X

更新日期：2019-06-27 00:00:00